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Raphaela T. Goldbach-Mansky, M.D., M.H.S., and Nicole Plass, R.N., B.S.N., M.P.A., with patient 2

This photograph shows Raphaela T. Goldbach-Mansky, M.D., M.H.S. (left) with a DIRA patient. Dr. Goldbach-Mansky is a tenure-track investigator in the NIAMS Intramural Research Program, Office of the Clinical Director, Translational Autoinflammatory Disease Section. She is assisted by Nicole Plass, R.N., B.S.N., M.P.A., LCDR, U.S. Public Health Service. Dr. Goldbach-Mansky‚Äôs research focus is on applying a systematic approach to the clinical and immunological description of a number of autoinflammatory diseases. Her lab uses targeted interventions to understand the role of specific inflammatory pathways in the pathogenesis of autoinflammatory diseases. The discovery of single-gene mutations in a number of autoinflammatory diseases has provided new targets to treat this disease group. Her studies in patients with neonatal-onset multisystem inflammatory disease, NOMID, have demonstrated the pivotal role of IL-1 beta oversecretion in the often devastating inflammatory manifestations of this disease. The overlap of clinical symptoms has led to the investigation of the role of IL-1 in other autoinflammatory/autoimmune diseases. Dr. Goldbach-Mansky has been involved in the identification of a new genetic immune disorder in children called DIRA (deficiency of the interleukin-1 receptor antagonist). This photograph was taken May 15, 2009, at the NIH Clinical Center, Pediatric Clinic, Exam Room I-6459, on the Bethesda campus of the National Institutes of Health. 

Nurses, Physicians, Patient, Child, Autoimmune Diseases, Clinical Care, Clinical Staff, Autoinflammatory Diseases, DIRA  

Goldbach-Mansky, Raphaela; patient; Plass, Nicole  


NIH Location:
NIH Clinical Center 

Image Number:

Image Date:

Date Entered:
August 18, 2009 

Rhoda Baer 

Image Type:

Public Domain - Public Access 

NIH Grant Number:

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